What is BCR-ABL normal range?

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What is BCR-ABL normal range?

One widely used prognostic index, the Sokal score, is calculated for patients aged 5-84 years by the following equation: Hazard ratio = exp 0.0116 (age – 43) + 0 .0345 (spleen size [cm below costal margin] – 7.5 cm) + 0.188 [(platelet count/700)2 – 0.563] + 0.0887 (% blasts in blood – 2.1)

Q. How is Sokal score calculated?

Sokal score, Euro score, and EUTOS score were calculated according to formulas given below at baseline. Sokal score = Exp [0.0116 × (age in years – 43.4) + 0.0345 × (spleen size – 7.51) + 0.188 9 ([platelet count ⁄ 700]2 – 0.563) + 0.0887 × (blast cell counts – 2.10)], where Exp is the exponential function [5].

Q. What is Sokal score?

One widely used prognostic index, the Sokal score, is calculated for patients aged 5-84 years by the following equation: Hazard ratio = exp 0.0116 (age – 43) + 0 .0345 (spleen size [cm below costal margin] – 7.5 cm) + 0.188 [(platelet count/700)2 – 0.563] + 0.0887 (% blasts in blood – 2.1)

Predicts survival of CML based on clinical and lab information. Use to predict prognosis at the time of CML diagnosis, before starting treatment. In the US, the Sokal Score can be used to determine risk and decide on therapy based on the NCCN guidelines for CML.

Q. What is accelerated phase CML?

Accelerated Phase. In the accelerated phase, the number of immature blast cells has risen, and sometimes new chromosomal changes, in addition to the Ph chromosome, will occur. ​People with accelerated phase CML may have. More than 20 percent basophils (type of white blood cell) in the bloodstream.

Q. What is BCR ABL?

BCR-ABL is a mutation that is formed by the combination of two genes, known as BCR and ABL. It’s sometimes called a fusion gene. The BCR gene is normally on chromosome number 22. The ABL gene is normally on chromosome number 9. The BCR-ABL mutation happens when pieces of BCR and ABL genes break off and switch places.

Q. What is complete cytogenetic response?

A complete cytogenetic response means no (or less than 1% of) cells in the bone marrow have the Philadelphia chromosome. A partial cytogenetic response means between 1% and 35% of the cells in the bone marrow still have the Philadelphia chromosome.

Q. What are the 3 phases of CML?

To help doctors plan treatment and predict prognosis, which is the chance of recovery, CML is divided into 3 different phases: chronic, accelerated, or blast. Chronic phase. The blood and bone marrow contain less than 10% blasts. Blasts are immature white blood cells.

Q. WHO criteria accelerated phase CML?

Accelerated phase (AP) is defined by the presence of ≥ 1 of the following criteria: 10 – 19% blasts in blood or marrow (Drug Des Devel Ther 2019;13:825) Persistent or increasing WBC > 10 x 10⁹/L, unresponsive to therapy. Persistent platelet count > 1,000 x 10⁹/L, unresponsive to therapy.

The effective measurement range for the international scale was deemed to be a BCR-ABL level of 10% IS or below. This was because most field methods used ABL as the control gene.

Q. What is BCR-ABL positive?

What is it used for? A BCR-ABL test is most often used to diagnose or rule out chronic myeloid leukemia (CML) or a specific form of acute lymphoblastic leukemia (ALL) called Ph-positive ALL. Ph-positive means a Philadelphia chromosome was found. The test is not used to diagnose other types of leukemia.

Q. How is cytogenetic response measured?

Cytogenetic response is based on the percentage of cells in a sample of your bone marrow that have the Philadelphia chromosome (and therefore are CML cells). This can be determined with either cytogenetics or FISH testing, both of which can find altered (mutated) chromosomes.

Q. What is DMR in CML?

The current thrust in CML investigation is to go beyond the achievement of MMR and to achieve a deep molecular response (DMR). This has been variously defined as > 4 or 4.5 log reduction. Patients achieving a DMR are potential candidates for treatment free remission trials.

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