What does Entrez BCL6 do?

HomeWhat does Entrez BCL6 do?
What does Entrez BCL6 do?

Q. What is the BCL6 gene?

Q. What is BCL6 a marker for?

BCL6 proto-oncogene is one of the markers for germinal center origin in DLBCL and encodes a transcriptional repressor factor. Mutation or translocation affecting this proto-oncogene has been implicated in the pathogenesis of certain subtypes of DLBCL.

Q. What is the BCL6 gene?

Q. Is BCL6 antiapoptotic?

Together, these observations strongly suggest that BCL6 plays an antiapoptotic role in various types of cells endogenously expressing BCL6, including germinal center B cells and lymphoma cells derived from these cells.

Q. What is bcl2 and BCL6?

Bcl-2 and Bcl-6 are two markers linked to germinal center B cells. The Bcl-2 gene, located at chromosome 18q21, encodes for a 25kd protein located mainly in the mitochondrial membrane. This Bcl-2 protein is an anti-apoptosis factor that is important in normal B-cell development and differentiation.

Q. Is double hit lymphoma curable?

“The outcomes were far better than we saw with previous analyses,” he noted, adding fluorescence in situ hybridization (FISH) analysis identify double-hit lymphoma in otherwise low-risk patients, who have a greater than 50% chance of cure.

Q. What is BCL2 and BCL6?

Q. Can triple hit lymphoma be cured?

There is no standard treatment for double-hit or triple-hit lymphoma. These types of lymphoma can be difficult to treat. They have a higher risk of coming back (relapsing) than more common types of high-grade B-cell lymphoma.

Q. How long can you live with double-hit lymphoma?

A 2014 multicenter retrospective study of 311 patients with double-hit lymphoma showed median progression-free survival to be 11 months and median overall survival to be 22 months.

GeneCards Summary for BCL6 Gene BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Primary Mediastinal Large B-Cell Lymphoma and Intravascular Large B-Cell Lymphoma. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and MECP2 and Associated Rett Syndrome.

Entrez Gene Summary for BCL6 Gene. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors.

Q. What is the role of BCL6 in B-cell lymphomagenesis?

BCL6 promotes epithelial-mesenchymal transition via enhancing the ZEB1-mediated transcriptional repression of E-cadherin in breast cancer cells. BCL6 may act by ‘hit-and-run’ in B-cell lymphomagenesis. Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 protein (BCL6) repression in lymphoma.

Q. What is the relationship between BCL-6 and maturation protein 1 (Blimp-1)?

Data show there was a positive correlation between B cell lymphoma 6 (Bcl-6) and B lymphocyte-induced maturation protein 1 (Blimp-1) at the level of mRNA. miR-155 overexpression plays a promoting role in the proliferative, migratory and invasive behavior of OSCC cells.

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~~~ Entrez ~~~Title: What is Entrez? Explain Entrez, Define Entrez, Meaning of EntrezCreated on: 2018-10-17Source Link: https://en.wikipedia.org/wiki/Entrez-…

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